Multi-system state shifts and cognitive deficits induced by chronic morphine during abstinence

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• 作者：Haichen Niu^a ; Guanqun Zhang^b ; ¹ ; Haiying Li^a ; Qiang Zhang^a ; Tongzhou Li^c ; Sheng Ding^c ; Lei Wang^d ; Zhonghai Zhang^a ; Yuehua Qiao^e ; ^{oto8558@163.com} ; Min Hu^f ; ^{fudanhumin@sina.com}
• 关键词：Morphine ; Manganese-enhanced MRI ; Withdrawal ; Cognitive
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：640
• 期：Complete
• 页码：144-151
• 全文大小：1617 K
• 卷排序：640

文摘

Morphine administration induced the withdrawal. Obvious cognitive deficit was found in withdrawal in rats. MEMRI maps the dysfunctional regions in withdrawal rats. Withdrawal disturbs the brain function leading to muti-systems state shifts.