Dosage compensation and chromatin structure in Drosophila
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- 作者：Bashaw ; Greg J ; Baker ; Bruce S
- 关键词：msl male-specific lethal ; ORF open reading frame ; Su(Hw) Suppressor of Hairy-wing ; Suvar Suppressors of position effect variegation ; SXL Sex-lethal ; UTR untranslated region
- 刊名：Current Opinion in Genetics & Development
- 出版年：1996
- 出版时间：August, 1996
- 年：1996
- 卷：6
- 期：4
- 页码：496-501
- 全文大小：640 K
文摘
The past year has brought significant advances in our understanding of the male-specific lethal (msl) genes and dosage compensation in Drosophila. The molecular characterization of the msl-2 gene has, to a great extent, solved the question of how msl-mediated dosage compensation is restricted to males. Molecular analyses of the msl genes have substantiated the proposal that the MSL proteins function as a multimeric complex to mediate dosage compensation. The finding that MSL-2 protein has a RING finger and the demonstration that an insulator protein facilitates the dosage compensation of X-linked genes inserted into the autosomes have opened promising avenues to identify the cis-acting dosage-compensation determinants.