Boundary and insulator elements in chromosomes

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• 作者：Gerasimova ; Tatiana I ; Corces ; Victor G
• 关键词：apoB apolipoprotein B ; AS-C achaete&mdash ; scute complex ; BEAF boundary element associated factor ; LCR locus control region ; MAR matrix attachment region ; mod(mdg4) modifier of mdg4 ; SAR scaffold attachment region ; su(Hw) suppressor of Hairy-wing ; Trl Trit
• 刊名：Current Opinion in Genetics & Development
• 出版年：1996
• 出版时间：April, 1996
• 年：1996
• 卷：6
• 期：2
• 页码：185-192
• 全文大小：841 K

文摘

Recent progress in understanding boundary and insulator elements has concentrated on the identification of their protein components. BEAF-32 is a protein present in the scs' element of Drosophila that is also localized to most interband regions and puffs of polytene chromosomes, suggesting a role in the organization of structural chromosomal domains. The suppressor of Hairy-wing and modifier of modg4 proteins have been characterized as components of the gypsy insulator. The latter seems to play a crucial role in conferring on the insulator its ability to unidirectionally affect enhancer function.