Stopped at the border: boundaries and insulators

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• 作者：Bell ; Adam C ; Felsenfeld ; Gary
• 关键词：BEAD-1 blocking element alpha/delta-1 ; eve even-skipped ; Pc-G Polycomb-Group ; PRE Polycomb response element ; RO repeat organizer ; Su(Hw) suppressor of Hairy wing ; TCR T-cell receptor ; trx-G trithorax-Group
• 刊名：Current Opinion in Genetics & Development
• 出版年：1999
• 出版时间：April, 1999
• 年：1999
• 卷：9
• 期：2
• 页码：191-198
• 全文大小：769 K

文摘

Boundaries in chromatin are often marked by the presence of insulator elements. New results in Drosophila have identified an insulator with a proven boundary function essential for development. Other studies suggest a connection between the activity of some insulators and Drosophila trithorax-Group and Polycomb-Group genes. Several examples of vertebrate insulators have now been found; their locations suggest important boundary functions. Enhancer-blocking studies in oocytes and position-effect studies in transformed cells shed new light on insulator mechanisms.