Long noncoding RNAs in aging and age-related diseases
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- 作者：Sukhleen Kour ; Pramod C. Rath ; pcrath@mail.jnu.ac.in" class="auth_mail" title="E-mail the corresponding author ; rathpuri@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aging ; LncRNAs ; Cellular senescence ; Chromatin ; Telomere ; Age-related diseases
- 刊名：Ageing Research Reviews
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：26
- 期：Complete
- 页码：1-21
- 全文大小：922 K
文摘
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Aging process involves decline in biological functions over the time.
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Pervasive transcription of lncRNAs in mammals regulates various cellular processes.
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LncRNAs could affect aging via chromatin modulation and telomere maintenance.
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Various p53 regulated and tumour suppressor lncRNAs could affect onset of aging.
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LncRNAs regulate various age-related diseases and disorders.