Essential oil of Curcuma aromatica induces apoptosis in human non-small-cell lung carcinoma cells
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- 作者：Jui-Wen Maa ; 1 ; Thomas Chang-Yao Tsaob ; 1 ; Yi-Ting Hsia ; Ying-Chao Linc ; d ; Yuhsin Chene ; Yeh Chenf ; Chi-Tang Hog ; Jung-Yie Kaoa ; biosjky@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Tzong-Der Waya ; h ; i ; tdway@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Non-small-cell lung cancer ; Curcuma aromatica Salisb ; Apoptosis ; Akt/NF-κB
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：22
- 期：Complete
- 页码：101-112
- 全文大小：2569 K
文摘
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Zingiberene, β-sesquiphellandrene and turmerone were found predominant compounds from Curcuma aromatica essential oil (CAEO).
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CAEO could promote tumour suppressor protein p53 expression.
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CAEO inhibited the phosphorylation of ERK1/2 and increased the phosphorylation of JNK1/2 and p38.
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CAEO treatment inhibited Akt/NF-κB signal pathways in NCI-H1299 cells.
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CAEO induced apoptosis and had a great potential to become a new anti-tumour candidate in human non-small-cell lung cancer.