TAp73 upregulates IL-1β in cancer cells: Potential biomarker in lung and breast cancer?

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• 作者：Polina Vikhreva^a ; Varvara Petrova^a ; Tarik Gokbulut^a ; ^b ; Ilias Pestlikis^c ; Mara Mancini^a ; Nicola Di Daniele^d ; Richard A. Knight^a ; Gerry Melino^a ; ^c ; Ivano Amelio^a ; ^{ia119@le.ac.uk}
• 关键词：Inflammation ; Interleukin ; p53 family ; Cytokines ; Immunotherapy
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：482
• 期：3
• 页码：498-505
• 全文大小：1133 K
• 卷排序：482

文摘

The p53 family member p73 controls a wide a range of biological processes required for its tumour suppressor functions. p73 regulates IL-1β expression, thus potentially affecting inflammasomes and inflammatory response. p73/IL-1β axis correlates with poor prognosis in lung and breast cancer.