The impact of Primary Ciliary Dyskinesia on the upper respiratory tract

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• 作者：Lucy C. Morgan¹ ; ² ; ³ ; ^{Lucy.morgan@sswahs.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author} ; Catherine S. Birman¹ ; ³ ; ⁴
• 关键词：Primary ciliary dyskinesia ; Chronic rhinosinusitis ; Chronic otitis media with effusion
• 刊名：Paediatric Respiratory Reviews
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：18
• 期：Complete
• 页码：33-38
• 全文大小：1524 K

文摘

Primary Ciliary Dyskinesia (PCD) is an autosomal recessive genetic condition affecting the function of motile cilia. The upper respiratory tract is lined with ciliated epithelium and hence a hallmark of PCD is the development, from the neonatal period onwards, of persisting secretion retention and suppurative infection in the middle ear, nose and facial sinuses [1]. This review aims to remind the clinician involved in the care of a patient with PCD of the complexities of making the diagnosis of chronic rhinosinusitis (CRS) and chronic otitis media with effusion (ChOME), the morbidity associated with CRS and ChOME and of current evidence of best practice for the management of these conditions.