Pt-based alloy/carbon black nanohybrids are synthesized in ionic liquid through using plasma. The nanohybrids are covered with a layer of ionic liquid supramolecules (ILSMs). An increase in the activity of the nanohybrid catalysts results from the ILSMs. The activity of the PtNiRu-IL/C catalyst is 10.8 times higher than those of c-Pt/C. The catalysts developed exhibit long-term stability as well as excellent activity for ORR.