Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing ‘click’ chemistry: DNA-binding affinity and anticancer activity
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- 作者：Ahmed Kamal ; N. Shankaraiah ; V. Devaiah ; K. Laxma Reddy ; Aarti Juvekar ; Subrata Sen ; Nisha Kurian ; Surekha Zingde
- 关键词：1 ; 2 ; 3-Triazoles ; Pyrrolo[2 ; 1-c][1 ; 4]benzodiazepines ; DNA-binding affinity ; Anticancer activity
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2008
- 出版时间：15 February 2008
- 年：2008
- 卷：18
- 期：4
- 页码：1468-1473
- 全文大小：156 K
文摘
1,2,3-Triazole based molecules are useful pharmacophores for several DNA-alkylating and cross-linking agents. A series of A/C8, C/C2 and A/C8-C/C2-linked 1,2,3-triazole–PBD conjugates have been synthesized by employing ‘click’ chemistry. These molecules have exhibited promising DNA-binding affinity and anticancer activity in selected human cancer cell lines.