The novel acid degradation products of losartan: Isolation and characterization using Q-TOF, 2D-NMR and FTIR
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- 作者：Avadhesh Kumar Pandey ; Ravi Rapolu ; Ch. Krishnam Raju ; Gururaj Sasalamari ; Sanath Kumar Goud ; Atul Awasthi ; axa@usp.org" class="auth_mail" title="E-mail the corresponding author ; atulpreet@rediffmail.com" class="auth_mail" title="E-mail the corresponding author ; Sameer G. Navalgund ; Koduru V. Surendranath
- 关键词：Losartan potassium ; Acidic degradation ; LC-QTOF-MS ; NMR ; FTIR ; Novel impurities
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：20 February 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：65-71
- 全文大小：1468 K
文摘
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Forced degradation of losartan in acidic condition.
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Isolation and characterization of degradation product.
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Structural elucidation using LC-QTOF-MS, 1D/2D NMR.
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Identification of positional dimers.