Synthesis and biological evaluation of pyrrolo[2,3-b]pyridine analogues as antiproliferative agents and their interaction with calf thymus DNA
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- 作者：Suresh Narvaa ; Surendar Chittia ; Bhaskara Rao Balab ; Mallika Alvalac ; Nishant Jainb ; Venkata Gowri Chandra Sekhar Kondapallia ; kvgc@hyderabad.bits-pilani.ac.in" class="auth_mail" title="E-mail the corresponding author ; kvgcs.bits@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pyrrolo[2 ; 3-b]pyridine ; 1 ; 2 ; 3-Triazole ; Calf thymus DNA ; Antiproliferative activity
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：23 May 2016
- 年：2016
- 卷：114
- 期：Complete
- 页码：220-231
- 全文大小：1509 K
文摘
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New 7-azaindole analogues were synthesized and evaluated for anticancer activity.
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Cytotoxic evaluation carried against A549, HeLa and MDA MB-231 cancer cell lines.
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5c, 5d, 5e, 5h, 5k, 5m, 5n, 5q, 5r, 7f, 7j, 7g and 7k exhibited maximum GI50.
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Molecular docking study was also performed.
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Docking pose for the active compounds 7f, 7g and 7i are shown.