Molecular features of bile salt hydrolases and relevance in human health

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• 作者：Deepak Chand¹ ; Vellore Sunder Avinash¹ ; Yashpal Yadav ; Archana Vishnu Pundle ; Cheravakattu Gopalan Suresh ; Sureshkumar Ramasamy ; ^{s.ramasamy@ncl.res.in}
• 关键词：Ntn hydrolase ; Bile ; Glucose homeostasis ; Lipid metabolism ; Cholesterol
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：2981-2991
• 全文大小：1408 K
• 卷排序：1861

文摘

Bile salt hydrolases (BSH) are significant as a part of probiotics. BSHs possess differential substrate spectrum and functions based on the environment. They influence bile acid signalling, altering host lipid and glucose homeostasis. Some BSHs are also involved in bacterial pathogenesis. Exploration of molecular features of BSH will help appreciate its multiple roles.