Hydrophilic interaction liquid chromatography-tandem mass spectrometry quantitative method for the cellular analysis of varying structures of gemini surfactants designed as nanomaterial drug carriers
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- 作者：McDonald Donkurua ; Deborah Michela ; Hanan Awada ; George Katselisb ; Anas El-Aneeda ; anas.el-aneed@usask.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：16-3-16 ; N ; N-bis(dimethylhexadecyl)-1 ; 3-propane-diammonium ; 16-3-16-d66 ; N ; N-bis(dimethylhexadecyl-d16)-1 ; 3-propane-diammonium ; 16(Py)-S-2-S-(Py)16 ; 1 ; 1&prime ; -[ethane-1 ; 2-diylbis(sulfanediylhexadecane-1 ; 2-diyl)]dipyridinium ; 16(Py)-S-2-S-(Py)16-d10 ; 1 ; 1&prime ; -[ethane-1 ; 2-diylbis(sulfanediylhexadecane-1 ; 2-diyl)]dipyridinium-d10 ; CID ; collision-induced dissociation ; DOPE ; 1 ; 2-dioleoyl-sn-glycero-3-phosphoethanolamine ; DESI ; desorption electrospray ionization ; DNA ; deoxyribonucleic acid ; ESI ; ele
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：1446
- 期：Complete
- 页码：114-124
- 全文大小：930 K
文摘
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An LC–MS/MS method for the quantification of 18 surfactants with varying structures was developed.
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Tested compounds belong to diquaternary ammonium gemini surfactant molecules.
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HILIC chromatography was employed allowing for a short simple isocratic run of only 4 min.
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The method was applied to assess the cellular uptake within PAM 212 cells for two lead compounds.