Binding of 12-s-12 dimeric surfactants to calf thymus DNA: Evaluation of the spacer length influence
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- 作者：Beatriz Sarrió ; na ; Eva Bernala ; Victoria Isabel Martí ; na ; Manuel Ló ; pez-Ló ; pezb ; Pilar Ló ; pez-Cornejoa ; Margarita Garcí ; a-Calderó ; nc ; Marí ; a Luisa Moyá ; a ; moya@us.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dimeric surfactants ; Calf thymus DNA ; Spacer length ; Charge inversion ; DNA compaction ; Electromotive force
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：311-318
- 全文大小：1602 K
文摘
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Biding of 12-s-12 dimeric surfactants to calf thymus DNA was investigated.
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Hydrophobic interactions mainly control the binding Gibbs energy.
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12-s-12/ctDNA complexation results in the charge inversion of the nucleic acid.
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Formation of 12-s-12/ctDNA complexes causes the compaction of DNA.
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12-s-12 surfactants with long spacers are the most efficient for DNA compaction.