Bacillus-produced surfactin attenuates chronic inflammation in atherosclerotic lesions of ApoE∿∿/sup> mice
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- 作者：Ping Gana ; Dong Jina ; Xiuyun Zhaoa ; Zhenqiu Gaoa ; b ; Shengying Wanga ; Peng Duc ; Gaofu Qia ; qigaofu@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Surfactin ; Anti-inflammation ; Atherosclerosis
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：226-234
- 全文大小：1751 K
文摘
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Bacillus-produced surfactin induces Tregs to inhibit chronic inflammation and attenuate atherosclerosis in mice.
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Tregs secrete IL-10 and TGF-β to create an anti-inflammatory milieu in the aorta wall for athero-protection.
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Surfactin has potential as a novel immunomodulator against atherosclerosis.