Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healing

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• 作者：Joseph S. Fernandez-Moure ; MD ; MS^a ; ^b ; ¹ ; ^{jsfernandez-moure@houstonmethodist.org} ; Jeffrey L. Van Eps ; MD^a ; ^b ; ¹ ; Fernando J. Cabrera ; MD^b ; Zonia Barbosa ; MD^a ; Guillermo Medrano del Rosal ; MD^b ; Bradley K. Weiner ; MD^b ; ^c ; Warren A. Ellsworth IV ; MD^d ; Ennio Tasciotti ; PhD^b
• 关键词：Platelet-rich plasma ; Wound ; Infection ; Neovascularization ; Musculoskeletal ; Healing
• 刊名：Journal of Surgical Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：207
• 期：Complete
• 页码：33-44
• 全文大小：2233 K
• 卷排序：207

文摘

Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in response to various physiologic triggers. Traditionally thought to be solely involved in the mechanisms of hemostasis, platelets have gained much attention due to their involvement wound healing, immunomodulation, and antiseptic properties. As the field of surgery continues to evolve so does the need for therapies to aid in treating the increasingly complex patients seen. With over 14 million obstetric, musculoskeletal, and urological and gastrointestinal surgeries performed annually, the healing of surgical wounds continues to be of upmost importance to the surgeon and patient. Platelet-rich plasma, or platelet concentrate, has emerged as a possible adjuvant therapy to aid in the healing of surgical wounds and injuries. In this review, we will discuss the wound healing properties of platelet-rich plasma and various surgical applications.