Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy

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• 作者：Marijke Eurelings ; Nicolette C. Notermans ; Henk M. Lokhorst ; Berris van Kessel ; Bart C. Jacobs ; John H.J. Wokke ; Surinder S. Sahota and Andries C. Bloem
• 关键词：Polyneuropathy ; Monoclonal gammopathy ; V gene analysis ; Anti-MAG ; Antiganglioside
• 刊名：Journal of Neuroimmunology
• 出版年：2006
• 出版时间：June 2006
• 年：2006
• 卷：175
• 期：1-2
• 页码：152-159
• 全文大小：140 K

文摘

Antineural antibody activity is the implicated pathogenic mechanism in polyneuropathy associated with monoclonal gammopathy. Recognition of antigen depends on immunoglobulin variable regions, encoded by V genes. We studied V_HDJ_H and V_LJ_L gene use in monoclonal B cells by clonal analysis in 20 patients with polyneuropathy and IgM monoclonal gammopathy. V genes associated with bacterial responses appear over-represented and V_H3–23 was preferentially used, without association with specific D, J_H or V_LJ_L. V genes revealed somatic mutation and intraclonal variation was found in 9 of 20 patients. Polyneuropathy associated with monoclonal gammopathy may be caused by an immune response to bacterial antigens, which recruit somatically mutated autoreactive B cells.