Brain targeted PLGA nanocarriers alleviating amyloid-螔 expression and preserving basal survivin in degenerating mice model
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- 作者：Bhasker Sriramojua ; Prasad Neeratib ; Rupinder K. Kanwara ; Jagat R. Kanwara ; jagat.kanwar@deakin.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：A尾 ; amyloid beta ; AchE ; acetyl cholinesterase ; AD ; Alzheimer's disease ; AGEs ; advanced glycation end products ; APP ; amyloid precursor protein ; BBB ; blood brain barrier ; d-Gal ; d-Galactose ; EAAT2 ; excitatory amino acid transporter 2 ; EDC ; 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride ; GFAP ; glial fibrillary acidic protein ; GSK ; glycogen synthase kinase ; IAPs ; inhibitor of apoptotic proteins ; NF ; neurofilament ; NHS ; N-hydroxysulfosuccinimide ; PVA ; poly vinyl alcohol ; SurR9 ; +
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：1852
- 期：11
- 页码：2423-2431
- 全文大小：2749 K
文摘
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SurR9-C84A nanoparticles were protective against the neurodegenerative and toxic insults.
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The nanoparticles prepared showed a size range of 150 nm ideal for crossing the blood brain barrier.
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Treatments preserved basal levels of survivin expression essential for neuronal survival.
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Treatments lowered amyloid-尾 expression and enhanced the neuronal integrity marker expression.