SurR9C84A protects and recovers human cardiomyocytes from hypoxia induced apoptosis

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• 作者：Ajay Ashok^a ; ^b ; Jagat Rakesh Kanwar^a ; Uma Maheswari Krishnan^c ; Rupinder Kaur Kanwar^a ; ^{rupinder.kanwar@deakin.edu.au}
• 关键词：Apoptosis ; Hypoxia ; Survivin ; SurR9C84A ; Cardiomyocytes
• 刊名：Experimental Cell Research
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：350
• 期：1
• 页码：19-31
• 全文大小：3267 K
• 卷排序：350

文摘

Protection/regeneration of dying myocardium post myocardial infarction is important. Downregulation of survivin induces apoptosis in hypoxic human cardiomyocytes (HCM). Bio-replenishment with SurR9-C84A reinstates HCM survival, recovery and growth. SurR9-C84A targets mitochondrial depolarization, fcTnT and ROS generation in HCM. SurR9-C84A upregulates survivin, PCNA, PI3K/Akt pathway, VEGF and HSP levels. SurR9-C84A holds promise as a treatment and preventive agent to replenish survivin.