Prevalence and characterization of fibrosis in surveillance liver biopsies of patients with Fontan circulation

详细信息    查看全文

• 作者：Lea F. Surrey ; MD^a ; ^{surreylf@email.chop.edu" class="auth_mail" title="E-mail the corresponding author} ; ^{lfsurrey@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Pierre Russo ; MD^a ; Jack Rychik ; MD^b ; David J. Goldberg ; MD^b ; Kathryn Dodds ; CRNP^b ; Michael L. O'Byrne ; MD ; MSCE^c ; Andrew C. Glatz ; MD ; MSCE^b ; Elizabeth B. Rand ; MD^d ; Henry C. Lin ; MD^d
• 关键词：CHOP ; The Children's Hospital of Philadelphia ; AST ; aspartate aminotransferase ; ALT ; alanine aminotransferase ; GGT ; γ-glutamyltranspeptidase ; AFP ; α-fetoprotein ; PT ; prothrombin time ; INR ; international normalized ratio ; IVC ; inferior vena cava ; %CD ; percent collagen deposition ; CHFS ; congestive hepatic fibrosis score ; ALC ; absolute lymphoctye count ; ANC ; absolute neutrophil count ; AP ; alkaline phosphatase ; BNP ; B natriuretic peptide ; WBC ; white blood cells
• 刊名：Human Pathology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：57
• 期：Complete
• 页码：106-115
• 全文大小：1423 K

文摘

The Fontan operation is a widely used palliative procedure in patients with single-ventricle anatomy that results in liver injury. As timely identification of liver fibrosis may result in management changes to Fontan patients, the aim of our study was to identify clinically meaningful semi quantitative/quantitative pathologic parameters for biopsy assessment. We performed a retrospective review of 74 liver needle biopsies from Fontan patients. Fibrosis was assessed using quantitative % collagen deposition by Sirius red image analysis, METAVIR, congestive hepatic fibrosis score, sinusoidal fibrosis score, and sinusoidal dilation score. Contemporaneous laboratory, hemodynamic, and ultrasound data were collected. Centrilobular and peri sinusoidal fibrosis was observed in all cases, with 39.2% high grade. Portal fibrosis was observed in 93.2%, with 36.2% high-grade (METAVIR F3-F4). Cirrhosis was observed in 5.4%. % Collagen deposition was increased over control tissue (P < .001) and correlated with time from Fontan (r = 0.3, P = .009) and prothrombin time (r = 0.25, P = .034). Mildly elevated prothrombin time/international normalized ratio was the only measure of liver function consistently associated with multiple high-grade fibrosis scores (METAVIR P = .046, sinusoidal fibrosis P = .018). Abnormal liver echotexture on ultrasound was associated with high-grade congestive hepatic fibrosis score (P = .03). Pathologic gradings and %CD correlated with each other (r = 0.48-0.8, P < .001). Hepatic fibrosis in Fontan patients in our study is universally present, appears to be time dependent, and correlates with few laboratory measurements of liver function. Careful assessment of needle liver biopsies lends a more meaningful measure of liver fibrosis in the Fontan patient than clinical and laboratory data, allowing for appropriate changes to patient management.