An affinity adsorption media that mimics heparan sulfate proteoglycans for the treatment of drug-resistant bacteremia
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- 作者：Keith R. McCrea ; KeithMcCrea@ExTheraMedical.com" class="auth_mail" title="E-mail the corresponding author ; Robert S. Ward
- 关键词：Drug resistance ; CRE ; MRSA ; ESBL ; Affinity adsorption ; Biomimetic Surfaces
- 刊名：Surface Science
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：648
- 期：Complete
- 页码：42-46
- 全文大小：709 K
文摘
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We demonstrate affinity adsorption of several drug-resistant pathogens from blood.
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End-point attached heparin acts as a biomimetic surrogate of heparan sulfate.
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MRSA, ESBL K. pneumoniae, CRE E. coli and CRE K. pneumoniae were removed.
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Lack of competitive binding between CRE and MRSA suggests different binding sites.
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Sorbent hemoperfusion may be an effective treatment for drug-resistant bacteremia.