Association of low serum creatinine, abnormal lipid profile, gender, age and ethnicity with type 2 diabetes mellitus in Trinidad and Tobago

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• 作者：B. Shivananda Nayak ; ^a ; ^{Shivananda.Nayak@sta.uwi.edu} ; ^{shiv25@gmail.com} ; Donna M. Butcher^a ; Shivanna Bujhawan^a ; Dominique Chang^a ; Simone Chang^a ; Diane Cabral-Samaroo^a ; Sandhya Cadan^a ; Vanessa Buchoon^a ; Lystra Budhram^a ; Melissa Boyce^a ; Surujpaul Teelucksingh^a
• 关键词：Low serum creatinine ; Lipid profile ; Diabetics
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：91
• 期：3
• 页码：342-347
• 全文大小：143 K

文摘

Objective

To study the association of low serum creatinine, abnormal lipid profile and demographic variables with type 2 diabetic Trinidadian subjects.

Methods

Data were obtained from a cohort of 1122 diabetic and non-diabetic patients from clinics in Trinidad. Variables measured included demographics, HbA1_c, serum creatinine, lipid profile values and diabetic status.

Results

The sample consisted of 476 males (61.6 % diabetic) and 646 females (50.3 % diabetic). Most patients (59.2 % ) were Indo-Trinidadian, 23.4 % were Afro-Trinidadian and 13.5 % were of ‘mixed’ and ‘other’ categories. The majority (55.1 % ) of the patients were diabetic and diabetics were older than non-diabetics (p = 0.000). Abnormal lipid profile OR = 0.728, CI (0.532, 0.994), serum creatinine categories OR = 1.520, CI (1.317, 1.754), gender OR = 0.690, CI (0.533, 0.892) and age groups OR = 1.305, CI (1.185, 1.437) were useful predictors of type 2 diabetes. Ethnicity was not a useful predictor: OR = 1.007, CI (0.869, 1.168). Serum creatinine (mean) was found to be lower in diabetics aged 21–50 than in their non-diabetic counterparts. However, above 50 years old, the reverse was true. Serum creatinine means were higher in males than in females (p = 0.000).

Conclusion

Abnormal lipid profile, gender, age and serum creatinine are associated with type 2 diabetes. While age and gender are non-modifiable risk factors, steps should be taken to monitor and control the serum creatinine and lipid profile values of diabetics and non-diabetics.