Chronic uranium contamination alters spinal motor neuron integrity via modulation of SMN1 expression and microglia recruitment
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- 作者：Brice Saint-Marc ; Christelle Elie ; Line Manens ; Karine Tack ; Marc Benderitter ; Yann Gueguen ; Chrystelle Ibanez ; chrystelle.ibanez@irsn.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Uranium ; Spinal cord ; Motor neurons ; Microglia ; Inflammation
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：8 July 2016
- 年：2016
- 卷：254
- 期：Complete
- 页码：37-44
- 全文大小：1528 K
文摘
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Uranium contamination induces a decrease of motor neuron number in rat spinal cord.
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Uranium contamination induces a decrease of expression of the survival protein SMN1.
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Uranium contamination increases the number of microglial cells in rat spinal cord.
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Results suggest potential overexpression of MCP-1 by motor neurons themselves.
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Results suggest the trigger of a neuroinflammation process.