Higher post-acute myocardial infarction plasma haptoglobin level is associated with poor long-term overall survival

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• 作者：Kuang-Hsing Chiang^a ; ^b ; Yung-Ta Kao^a ; Hsin-Bang Leu^c ; ^d ; ^e ; ^f ; Po-Hsun Huang^c ; ^e ; ^f ; Shao-Sung Huang^c ; ^d ; ^e ; ^f ; Tsai-Mu Cheng^g ; ^{tmcheng@tmu.edu.tw} ; Ju-Pin Pan^c ; ^h ; ^{jppan@vghtpe.gov.tw}
• 关键词：Acute myocardial infarction ; Haptoglobin ; Survival
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：229
• 期：Complete
• 页码：102-107
• 全文大小：322 K
• 卷排序：229

文摘

To evaluate the association of post-acute myocardial infarction (AMI) plasma haptoglobin (Hp) levels with long-term overall survival in AMI patients.Methods and resultsPatients who were diagnosed of AMI were recruited and their Hp phenotypes and plasma levels were determined. According to previously reported cutoff point for Hp level (288.4 ng/ml), patients were classified as higher Hp group (> 288.4 ng/ml) and lower Hp group (≤ 288.4 ng/ml). The primary outcome was overall survival. This study recruited and followed a total of 117 patients for a median of 11.0 (3.2–17.6) years. Higher Hp group had 46 patients (39.3%) and lower Hp group had 71 patients (60.7%). Twelve patients had Hp 1-1 (10.3%), 50 with Hp 2-1 (42.7%), and 55 with Hp 2-2 (47.0%). The lower Hp group had significantly better overall survival (174.1 [51.6–212.5] vs. 106.5 [22.2–209.1], P = 0.037). There was no significant difference in overall survival between the three phenotype groups (P = 0.477). Multivariate regression analysis revealed that increased age (adjusted HR = 1.06, 95% CI: 1.03–1.10, P < 0.001) and higher Hp level (adjusted HR = 1.65, 95% = 1.02–2.67, P = 0.040) were significantly associated with poor overall survival.ConclusionHigher post-AMI plasma Hp level was independently associated with poor overall survival in AMI patients. No significant difference in overall survival was noted between three Hp phenotype groups. Acute phase Hp level might reflect the severity of oxidative stress during inflammation process.