The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients
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- 作者：Irene Escribano-Lopeza ; 1 ; Noelia Diaz-Moralesa ; 1 ; Susana Rovira-Llopisa ; b ; Arantxa Martinez de Marañ ; ona ; Samuel Ordenc ; Angeles Alvarezc ; Celia Bañ ; ulsa ; b ; Milagros Rochaa ; b ; c ; Michael P. Murphyd ; Antonio Hernandez-Mijaresa ; b ; e ; Victor M. Victora ; b ; c ; f ; victor.victor@uv.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：BMI ; body mass index ; DBP ; diastolic blood pressure ; HbA1c ; glycated hemoglobin ; HDL ; high density lipoprotein cholesterol ; HOMA-IR ; homeostasis model assessment of insulin resistance ; hs-CRP ; high-sensitive C-reactive protein ; HUVEC ; human umbilical vein endothelial cells ; IR ; insulin resistance ; LDL ; low density lipoprotein cholesterol ; PMN ; polymorphonuclear leukocytes ; SBP ; systolic blood pressure ; T2D ; type 2 diabetes ; TPP ; triphenylphosphonium
- 刊名：Redox Biology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：10
- 期：Complete
- 页码：200-205
- 全文大小：571 K
文摘
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Mitochondrial ROS production was enhanced in diabetic leukocytes and reduced by MitoQ.
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MitoQ treatment increased GPX-1 levels in T2D leukocytes.
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MitoQ increased PMN rolling velocity and decreased PMN rolling flux and adhesion.
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NFκB-p65 and TNFα were augmented in T2D and were both reduced by MitoQ treatment.
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MitoQ should be investigated as a novel means of reducing cardiovascular risk in T2D.