- 作者：Gaia Cattadori ; Karlman Wasserman ; Chiara Meloni ; Saima Mustaq ; Mauro Contini ; Anna Apostolo ; Daniele Andreini ; Damiano Magrì ; Susanna Sciomer ; Fabrizio Veglia ; Giovanni Berna ; Giovanni Introcaso ; Pietro Palermo ; Cesare Fiorentini ; Piergiuseppe Agostoni
- 关键词：Exercise ; heart failure ; brain natriuretic peptide ; lung diffusion
- 刊名：Journal of Cardiac Failure
- 出版年：2009
- 出版时间：March 2009
- 年：2009
- 卷：15
- 期：2
- 页码：136-144
- 全文大小：466 K
BackgroundIn left ventricular failure (LVF) patients, brain natriuretic peptide (BNP), lung diffusion for carbon monoxide (DLCO), and alveolar-membrane conductance (DM) correlate with LVF severity and prognosis. The reduction of DLCO and DM during exercise reflects pulmonary edema formation.Methods and Results
To evaluate, in LVF patients, the correlation between BNP and lung diffusion parameters at rest and during exercise, we studied 17 severe LVF patients, 13 moderate, and 10 normals measuring BNP and lung diffusion parameters before, at the end, and 1 hour after a 10-minute high-intensity constant-workload exercise. At rest, a significant correlation exists between BNP and lung diffusion parameters. Resting BNP, DLCO, and DM correlate with peak oxygen consumption (P < .0001 for all analyses). With exercise, BNP increase is significant (severe LVF 180 ± 49 pg/mL, moderate 68 ± 58, normals 18 ± 12); differently, only in severe LVF, with exercise, DLCO (–1.1 ± 0.7 mL/mm Hg/min, P < .0001) and DM (–6.4 ± 2.8, P < .0006) decrease. One hour after exercise, only in severe LVF, BNP is still higher than at rest, while DLCO, DM, and DM/Vc are lower. Significant correlations are observed between BNP and DM changes during exercise and recovery (P < .0001) in severe LVF.
Conclusions
In severe LVF, BNP changes during exercise correlate with simultaneous reductions in DM, suggesting that BNP increase and pulmonary edema formation could be related.