Pathogenicity and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant in susceptible animals
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- 作者：Xin Cong1 ; Jian-Lin Lei1 ; Shui-Li Xia1 ; Yi-Min Wang ; Yongfeng Li ; Su Li ; Yuzi Luo ; Yuan Sun ; sunyuan@hvri.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Hua-Ji Qiu ; huajiqiu@hvri.ac.cn" class="auth_mail" title="E-mail the corresponding author ; qiuhuaji@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pseudorabies virus ; gE/gI/TK-gene-deleted mutant ; Pathogenicity ; Immunogenicity ; Susceptible animals
- 刊名：Veterinary Microbiology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：182
- 期：Complete
- 页码：170-177
- 全文大小：1613 K
文摘
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We generated a gE/gI/TK-deleted mutant rPRVTJ-delgE/gI/TK based on a PRV variant.
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rPRVTJ-delgE/gI/TK displayed higher safety than rPRVTJ-delgE/gI in susceptible animals.
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rPRVTJ-delgE/gI/TK induced antibodies and protection comparable to rPRVTJ-delgE/gI.