Multidrug transporters and organic anion transporting polypeptides protect insects against the toxic effects of cardenolides

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• 作者：Simon C. Groen^a ; ^{sg189@nyu.edu} ; Erika R. LaPlante^a ; ^b ; Nicolas M. Alexandre^a ; ^b ; Anurag A. Agrawal^c ; ^d ; Susanne Dobler^e ; Noah K. Whiteman^a ; ^b ; ^{whiteman@berkeley.edu}
• 关键词：Drosophila melanogaster ; Cardenolide ; Na/K-ATPase ; Multidrug transporter/P-glycoprotein ; Organic anion transporting polypeptide ; Herbivore
• 刊名：Insect Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：81
• 期：Complete
• 页码：51-61
• 全文大小：1345 K
• 卷排序：81

文摘

Plants such as milkweeds and foxglove produce cardenolides in defense against animal feeding. We used Drosophila as a model to investigate how non-adapted animals respond to cardenolide ingestion. Cardenolide toxicity to Drosophila is high at levels found in plants and correlates negatively with polarity. Conserved Mdr (P-gp) and Oatp transporters are important in providing protection against ingested toxins. Drosophila Mdr and Oatp knockout mutant flies are more susceptible to cardenolides than wildtype flies.