The Salmonella effector SopB prevents ROS-induced apoptosis of epithelial cells by retarding TRAF6 recruitment to mitochondria
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- 作者：Haihua Ruana ; ruanhaihua@tjcu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhen Zhanga ; Li Tianb ; Suying Wanga ; Shuangyan Hua ; Jian-Jun Qiaob ; jianjunq@tju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Salmonella infection ; SopB ; ROS ; TRAF6 ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：16 September 2016
- 年：2016
- 卷：478
- 期：2
- 页码：618-623
- 全文大小：1301 K
文摘
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S. typhimurium effector protein SopB prevents infection-induced host cell apoptosis.
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We investigated the mechanism of SopB-mediated apoptosis suppression.
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SopB functioned by attenuating ROS production in mitochondria.
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SopB binds to TRAF6 and to prevent mitochondrial recruitment of TRAF6.