Rapid and efficient microwave-assisted sulfate modification of lentinan and its antioxidant and antiproliferative activities in vitro

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• 作者：Yili Feng ; Weiqi Li ; Xueqian Wu ; Liang He ; Suyun Ma
• 关键词：Lentinan ; Sulfation ; Microwave ; Structure ; Antioxidant and antiproliferative activities
• 刊名：Carbohydrate Polymers
• 出版年：2010
• 出版时间：15 October 2010
• 年：2010
• 卷：82
• 期：3
• 页码：605-612
• 全文大小：303 K

文摘

Lentinan (LNT) is a highly functional biomacromolecule, and its sulfated derivatives (sLNT) exhibit improved pharmacological properties compared to LNT. In the present study, LNT extracted from the fermentation broth of Lentinus edodes was sulfated using two methods, conventional heating and novel microwave radiation, and their biological activities were evaluated using an antioxidant system and an antiproliferation cell model. Our results indicate that the two sulfated derivates have similar physicochemical properties and spectroscopic profiles. Nevertheless, microwave radiation produced a higher yield of sLNT, with a shorter processing time and lower degradation. In contrast to LNT, the sLNT derivatives exhibited a strong antioxidant activity in vitro. In addition, the derivatives exhibited a significant antiproliferative effect on leukemia cells, whereas LNT exhibited the opposite outcome.