Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

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• 作者：Daniel A. Ritt¹ ; Mar&iacute ; a T. Abreu-Blanco² ; Lakshman Bindu² ; David E. Durrant¹ ; Ming Zhou² ; Suzanne I. Specht¹ ; Andrew G. Stephen² ; Matthew Holderfield² ; Deborah K. Morrison¹ ; ³ ; ^{morrisod@mail.nih.gov}
• 关键词：Ras pathway ; Sos ; Ras ; Raf ; ERK cascade ; JNK cascade ; phosphorylation ; rigosertib
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：64
• 期：5
• 页码：875-887
• 全文大小：4074 K
• 卷排序：64

文摘

Route for the phospho-inhibition of Ras pathway signaling mediated by JNK cascade Stress-induced S/TP phosphorylation inhibits the function of Sos1 and the Rafs S/TP phospho-regulatory circuit may act as a stress-induced signaling checkpoint S/TP circuit engaged by cancer drugs that activate JNK via mitotic/oxidative stress