Pharmacological analysis of hemodynamic responses to Lachesis muta (South American bushmaster) snake venom in anesthetized rats
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- 作者：Lourdes Diasa ; Mariana A.P. Rodriguesa ; Bruna R. Inouea ; Renata L. Rodriguesa ; André ; L. Rennó ; a ; Valé ; ria B. de Souzaa ; Frank D. Torres-Huacoa ; Norma C. Sousaa ; Alessandra Strokaa ; Anibal R. Melgarejob ; Stephen Hyslopa ; hyslop@fcm.unicamp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cholinergic neurotransmission ; Hypotension ; Kinin ; Lachesis muta venom ; Nitric oxide ; Pulmonary thrombosis
- 刊名：Toxicon
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：25-44
- 全文大小：3979 K
文摘
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The pharmacology of L. muta venom-induced hypotension was investigated in rats.
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Nitric oxide has a protective role in venom-induced hypotension.
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Arachidonic acid metabolites, kinins and cholinergic mechanisms are not involved.
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SVSPs and SVMPs contribute to pulmonary thrombosis and SVSPs to venom lethality.
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The NO/sGC/cGMP pathway is a major signaling pathway in venom-induced responses.