Swainsonine-induced apoptosis pathway in cerebral cortical neurons
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- 作者：Hao Lu ; Feng Ma ; Liang Zhang ; Jianguo Wang ; Chenchen Wu ; Baoyu Zhao ; zhby668@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Swainsonine ; Cerebral cortical neurons ; Apoptosis ; Death receptor pathway ; Endoplasmic reticulum stress
- 刊名：Research in Veterinary Science
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：102
- 期：Complete
- 页码：34-37
- 全文大小：618 K
文摘
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Swainsonine is the only toxin of locoweeds, and it can cause the locoism, a chronic neurological disease.
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Swainsonine-induced apoptosis of the cerebral cortical neurons was observed for the first time in vitro.
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Swainsonine induced the apoptosis of neurons through a death receptor pathway and endoplasmic reticulum stress.