The metabolic fate and receptor interaction of 16α-hydroxyprogesterone and its 5α-reduced metabolite, 16α-hydroxy-dihydroprogesterone

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• 作者：Desmar&eacute ; van Rooyen ; Therina du Toit ; Renate Louw-du Toit ; Donita Africander ; Pieter Swart ; Amanda C. Swart ; ^{acswart@sun.ac.za}
• 关键词：Adrenal 16α-hydroxyprogesterone ; SRD5A ; CYP11B2 ; AKR1C2 ; Progesterone receptor ; UHPLC-MS/MS
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：441
• 期：Complete
• 页码：86-98
• 全文大小：991 K
• 卷排序：441

文摘

UHPLC-MS/MS analyses identifies novel 16OHP4 metabolites. 16OHP4 is 11β-hydroxylated by CYP11B2, and subsequently reduced by SRD5A. 16OHP4 is 5α- and 3α reduced by SRD5A and AKR1C2 to 16Pdione and 16Pdiol. 5α-reduced P4 exhibits partial agonist activity towards PR-A and PR-B. 16Pdione exhibits weak agonist activity towards AR and PRs.