Melatonin-analog, β-methyl-6-chloromelatonin, supplementation in spinal cord injury

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• 作者：Dominic B. Fee ; Karin R. Swartz ; Nicole Scheff ; Kelly Roberts ; Prasad Gabbita ; Stephen Scheff
• 关键词：β ; -Methyl-6-chloromelatonin ; Melatonin analog ; Spinal cord injury ; Contusional injury
• 刊名：Brain Research
• 出版年：2010
• 出版时间：22 June 2010
• 年：2010
• 卷：1340
• 期：Complete
• 页码：81-85
• 全文大小：189 K

文摘

Spinal cord injury (SCI) is a devastating condition. Melatonin supplementation has been shown to lessen SCI, but its use has been limited by its side effect profile. In this work, rats underwent a moderate-to-severe contussional SCI with either placebo or β-methyl-6-chloromelatonin, 10 mg/kg or 100 mg/kg supplementation. The 10 mg/kg supplementation demonstrated benefit; the 100 mg/kg dosage was limited by toxicity. This is the first work to assess a melatonin analog in SCI.