TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia
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- 作者：Thomas H. Shina ; b ; Christopher Brynczkaa ; Farshid Dayyania ; Miguel N. Riverac ; David A. Sweetser ; M.D ; Ph.Da ; dsweetser@partners.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：AML1-ETO ; Acute myeloid leukemia ; Tumor suppressor ; TLE4 ; Inflammation ; Wnt signaling
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：46-56
- 全文大小：2668 K
文摘
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Loss of TLE4 tumor suppressor cooperates with AML1-ETO in acute myeloid leukemia.
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Loss of TLE4 activates Wnt signaling and pro-inflammatory genes.
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TLE4 loss triggers leukemia cell proliferation and blocks differentiation.
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TLE4 loss leads to chemotherapy resistance.
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These pro-leukemic effects are blocked by COX inhibition.