WY-14643, a selective agonist of peroxisome proliferator-activated receptor-α, ameliorates lipopolysaccharide-induced depressive-like behaviors by preventing neuroinflammation and oxido-nitrosative stress in mice

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• 作者：Rongrong Yang^a ; Peng Wang^b ; ^c ; Zhuo Chen^d ; Wenfeng Hu^b ; ^c ; Yu Gong^b ; ^c ; Wei Zhang^b ; ^c ; Chao Huang^b ; ^c ; ^{huachao@ntu.edu.cn}
• 关键词：ANOVA ; analysis of variance ; BDNF ; brain derived neurotrophic factor ; CSDS ; chronic social defeat stress ; DMSO ; dimethyl sulfoxide ; FST ; forced swimming test ; GSH ; glutathione ; IL-1β ; interleukin-1β ; IL-6 ; interleukin-6 ; LPS ; lipopolysaccharide ; MDA ; malondialdehyde ; NO ; nitric oxide ; OFT ; open field test ; PPAR-α ; peroxisome proliferator-activated receptor-α ; ROS ; reactive oxygen species ; TNF-α ; tumor necrosis factor-α ; TST ; tail suspension test
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：153
• 期：Complete
• 页码：97-104
• 全文大小：858 K
• 卷排序：153

文摘

WY-14643 pretreatment ameliorates LPS-induced depressive symptoms. WY-14643 inhibits neuroinflammation in both hippocampus and prefrontal cortex. WY-14643 inhibits LPS-induced oxido-nitrosative stress in brain tissues. WY-14643 improves LPS-induced decrease in BDNF levels in brain tissues.