Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells
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- 作者：Claudia Volpia ; 1 ; Giada Mondanellia ; 1 ; Maria T. Pallottaa ; 1 ; Carmine Vaccaa ; Alberta Iaconoa ; Marco Gargaroa ; Elisa Albinia ; Roberta Bianchia ; Maria L. Belladonnaa ; Sylvain Celanireb ; Cé ; line Mordantb ; Madeleine Herouxb ; Isabelle Royer-Uriosb ; Manfred Schneiderb ; Pierre-Alain Vitteb ; Mathias Cacquevelb ; Laurent Galibertb ; Sonia-Maria Polib ; Aldo Solaric ; Silvio Bicciatod ; Mario Calvittia ; Cinzia Antognellia ; Paolo Puccettia ; Ciriana Orabonaa ; 2 ; Francesca Fallarinoa ; 2 ; Ursula Grohmanna ; 2 ; ugrohmann@tin.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuroinflammation ; Autoimmunity ; mGluR4 ; Noncanonical GPCR signaling ; PI3K ; Src kinase ; Tryptophan metabolism ; Indoleamine 2 ; 3-dioxygenase 1 ; Dendritic cells ; Immune regulation
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：102
- 期：Complete
- 页码：59-71
- 全文大小：1804 K
文摘
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ADX88178, a selective mGluR4 PAM, exerts long-term therapeutic effects in RR-EAE.
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ADX88178 activates a noncanonical mGluR4 signaling in DCs.
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ADX88178 induces a tolerogenic functional phenotype in DCs via immunoregulatory IDO1.
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Highly selective mGluR4 PAMs may represent novel drugs in chronic neuroinflammation.