Regulation of tyrosine-containing activation motif-dependent cell signalling by FcγRII

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• 作者：Marc Daë ; ron ; Odile Malbec ; Sylvain Latour ; Eric Espinosa ; Patrick Pina ; Wolf H. Fridman
• 关键词：Fc receptor ; T-cell receptor ; Regulation of cell activation ; Mast cell ; T cell
• 刊名：Immunology Letters
• 出版年：1995
• 出版时间：2 January 1995
• 年：1995
• 卷：44
• 期：2-3
• 页码：119-123
• 全文大小：616 K

文摘

Crosslinking of the B-cell receptor (BCR) for antigen to low-affinity receptors for IgG (FcγRII) inhibits B-cell activation induced by BCR aggregation. The cell-triggering properties of the BCR depend on tyrosine-containing activation motifs (TAM), in the intracytoplasmic domain of its Igα and Igβ subunits. TAMs also account for the cell-triggering capabilities of the T-cell receptor (TCR) for antigen, in T lymphocytes, and of the high-affinity receptor for IgE (FcRI), in mast cells. Using as a model, rat basophilic leukemia cells (RBL-2H3) stably transfected with cDNA encoding wild-type or mutated murine or human FcγRIIB and chimeric molecules having the intracytoplasmic domain of the FcR γ subunit or of TCR-CD3 ζ subunit, we found that the inhibitory properties of FcγRII are neither restricted to B cells nor to BCR-dependent cell activation, but can be extended to other cells and, as a general rule, to TAM-dependent cell activation.