Tryptophan catabolism generates autoimmune-preventive regulatory T cells

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• 作者：Francesca Fallarino ; Ursula Grohmann ; Sylvaine You ; Barbara C. McGrath ; Douglas R. Cavener ; Carmine Vacca ; Ciriana Orabona ; Roberta Bianchi ; Maria L. Belladonna ; Claudia Volpi ; et al.
• 关键词：Dendritic cells ; Regulatory T cells ; Tryptophan
• 刊名：Transplant Immunology
• 出版年：2006
• 出版时间：December 2006
• 年：2006
• 卷：17
• 期：1
• 页码：58-60
• 全文大小：131 K

文摘

Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4⁺CD25⁻ cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo.