Restrictive Lung Function Is Related to Sympathetic Hyperactivity in Patients With Heart Failure

详细信息    查看全文

• 作者：Shuji Joho ; MD ; ^{sjoho@med.u-toyama.ac.jp} ; Ryuichi Ushijima ; MD ; Takashi Akabane ; MD ; Tadakazu Hirai ; MD ; Hiroshi Inoue ; MD
• 关键词：Heart failure ; restrictive lung function ; sympathetic nerve activity
• 刊名：Journal of Cardiac Failure
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：23
• 期：2
• 页码：96-103
• 全文大小：664 K
• 卷排序：23

文摘

Deactivation of pulmonary stretch receptors is a cause of sympathetic overactivation in patients with heart failure, but it remains unknown whether impaired lung function is independently associated with sympathetic overactivation. Decreased functional vital capacity was an independent predictor of increased level of direct measures of sympathetic nerve outflow. Changes in percentage of vital capacity negatively correlated with those in sympathetic nerve activity during follow-up. Restrictive lung function is associated with increased sympathetic nerve activity independently from heart failure severity.