How Best to Assess the Quality of Life in Long-Term Survivors After Surgery for NSCLC? Comparison Between Clinical Predictors and Questionnaire Scores

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• 作者：Silvia Sterzi¹ ; Alfredo Cesario² ; ³ ; Giacomo Cusumano² ; Giuseppe Corbo⁴ ; Filippo Lococo² ; ^{filippo_lococo@yahoo.it} ; Barbara Biasotti⁵ ; Luisa Maria Lapenna⁶ ; Giovanni Magrone¹ ; Valentina Dall'armi⁷ ; Elisa Meacci² ; Venanzio Porziella² ; Stefano Bonassi⁷ ; Stefano Margaritora² ; Pierluigi Granone²
• 关键词：Long-term lung cancer survivors ; Lung carcinoma ; Pulmonary function ; QOL ; Questionnaire
• 刊名：Clinical Lung Cancer
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：14
• 期：1
• 页码：78-87
• 全文大小：354 K

文摘

Background

The determinants and predictors of QOL in lung cancer survivors who have received surgery remain defined vaguely and still debated. We evaluate clinical, surgical, and pulmonary function characteristics as predictors of QOL in long-term lung cancer survivors who received surgery.

Methods

Quality of life was evaluated 5 years after surgery in 67 lung cancer patients using the European Organization for Research and Treatment of Cancer (EORTC) QOL Core Questionnaire, its lung cancer-specific module QLQ LC-13, and the Hospital Anxiety and Depression Scale questionnaire. Preoperative clinical, surgical, and pathologic data were matched with the questionnaire scores.

Results

Sex was associated with role functioning and symptoms, with males more often reporting fatigue and pain, appetite loss, coughing, and hemoptysis (P < .05). Lower education was associated with better cognitive functioning (P < .05). Symptoms were worse for younger patients and for those with major comorbidity. Histology marginally influenced the global health status (P < .10) and the cognitive functioning (P < .05). Patients receiving complementary therapy more easily suffered from fatigue and insomnia (P < .05), and to a lesser extent from nausea and vomiting, constipation, and stress related to financial difficulties (P < .10). Higher values of forced expiratory volume at the first second (FEV₁) and forced vital capacity (FVC) were significantly (P < .05) associated with a lower frequency of nausea and vomiting and appetite loss, while low percentage levels of FEV₁ and FVC were associated with lower global function and a greater severity of specific and nonspecific symptoms (P < .10 and P < .05).

Conclusions

Several preoperative features, particularly those reflecting pulmonary function, were moderately associated with QOL in long-term survivors and may be useful to address therapeutic strategies in lung cancer patients after surgery.