Ganglioside GQ1b enhances asynchronous dopamine release from PC12 cells and rat striatal slices.
Intracellular Ca2 + is a major factor in GQ1b induced DA release.
Pyk2 inhibition abolishes GQ1b induced DA release.
Autophosphorylation of Pyk2 is essential for GQ1b-evoked DA release.
Pyk2 intermediates GQ1b induced activation of ERK1/2 and DA release.
Phosphorylation of Synapsin I and depolymerization of actin are the main causes of GQ1b induced DA release.