Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats
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- 作者：Liana R. Steina ; &dagger ; ; Kazuko A. O&rsquo ; Della ; b ; Michiyo Funatsua ; Charles F. Zorumskia ; b ; c ; d ; Yukitoshi Izumia ; b ; c ; izumiy@wustl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACSF ; artificial cerebrospinal fluid ; Creb ; cAMP response element-binding protein ; D ; L-APV ; 2-amino-5-phosphonovarelic acid ; EE ; environmental enrichment ; fEPSP ; field excitatory postsynaptic potential ; H&E ; hematoxylin and eosin ; HFS ; high-frequency stimulation ; LFS ; low-frequency stimulation ; LTD ; long-term depression ; LTP ; long-term potentiation ; Map2 ; microtubule-associated protein 2 ; NMDAR ; N-methyl-d-aspartate receptor ; NPY ; neuropeptide Y ; PS ; population spike ; VDCC ; voltage-dependent cal
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：4 August 2016
- 年：2016
- 卷：329
- 期：Complete
- 页码：294-305
- 全文大小：2010 K
文摘
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Standard stimulus hippocampal LTP and LTD could not be induced in aged rats housed under normal conditions.
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LTP and LTD could be induced in aged rats after short-term environmental enrichment.
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The LTP induced in aged rats after short-term environmental enrichment was NMDAR-dependent.
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Short-term environmental enrichment selectively enhanced phospho-Creb and Vegf expression in aged rats.
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Short-term environmental enrichment resulted in weight loss in aged rats.