Behavioral effects of chronic stress in the Fmr1 mouse model for fragile X syndrome

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• 作者：Valerie Lemaire-Mayo^a ; ^b ; Enejda Subashi^a ; ^b ; Nadia Henkous^a ; ^b ; Daniel Beracochea^a ; ^b ; Susanna Pietropaolo^a ; ^b ; ^{susanna.pietropaolo@u-bordeaux.fr}
• 关键词：Fragile X Syndrome ; Chronic stress ; Social behavior ; Cognition ; Open field ; Fmr1 mouse
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：320
• 期：Complete
• 页码：128-135
• 全文大小：1378 K
• 卷排序：320

文摘

Behavioral sensitivity to stress was dramatically reduced in Fmr1-KO mice, the main animal model of Fragile X Syndrome. Repeated exposure to stress induced social and cognitive deficits only in WT mice. Chronic stress did not affect exploration, anxiety-like behaviors or corticosterone levels. The impact of stress depended on the type of stressors (restraint versus unpredictable stress) and the behavior tested.