Brentuximab vedotin for treatment of non-Hodgkin lymphomas: A systematic review

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• 作者：Garrett K. Berger^a ; ¹ ; Ali McBride^a ; ¹ ; Stephanie Lawson^a ; Kelsey Royball^a ; Seongseok Yun^b ; Kevin Gee^c ; Irbaz Bin Riaz^b ; Ahlam A. Saleh^d ; Soham Puvvada^b ; ² ; Faiz Anwer^e ; ² ; ^{anwerf@email.arizona.edu} ; ^{mhalajia@email.arizona.edu}
• 关键词：Brentuximab vedotin ; Relapse or refractory NHL ; CD30
• 刊名：Critical Reviews in Oncology/Hematology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：109
• 期：Complete
• 页码：42-50
• 全文大小：726 K
• 卷排序：109

文摘

Brentuximab vedotin (BV) is an antibody-drug conjucate (ADC) comprising a CD30-directed antibody, conjugated to the microtubule-disrupting agent MMAE via a protease cleavable linker. BV is FDA approved for use in relapsed classical Hodgkin lymphoma (HL) and relapsed systemic anaplastic large cell lymphoma (sALCL). There are multiple publications for its utility in other malignancies such as diffuse large B-cell lymphoma (DLBCL), mycosis fungoides (MF), Sézary syndrome (SS), T-cell lymphomas (TCL), primary mediastinal lymphoma (PMBL), and post-transplant lymphoproliferative disorders (PTLD). We believe that BV could potentially provide a strong additional treatment option for patients suffering from NHL.ObjectivePerform a systematic review on the use of BV in non-Hodgkin lymphoma (NHL) and other CD30+ malignancies in humans.Data sourcesWe searched various databases including PubMed (1946–2015), EMBASE (1947–2015), and Cochrane Central Register of Controlled Trials (1898–2015).Eligibility criteriaInclusion criteria specified all studies and case reports of NHLs in which BV therapy was administered.Included studiesA total of 28 articles met these criteria and are summarized in this manuscript.ConclusionOur findings indicate that BV induces a variety of responses, largely positive in nature and variable between NHL subtypes. With additional, properly powered prospective studies, BV may prove to be a strong candidate in the treatment of various CD30+ malignancies.