- 作者：Javier Narvá ; ez ; MD ; PhD? ; 1 ; 31577edd@comb.cat ; fjnarvaez@bellvitgehospital.cat ; Jose Antonio Narvá ; ez ; MD&dagger ; ; 1 ; Matí ; as de Albert ; MD&dagger ; ; Carmen Gó ; mez-Vaquero ; MD ; PhD? ; Joan Miquel Nolla ; MD ; PhD?
- 关键词：early psoriatic arthritis ; early rheumatoid arthritis ; magnetic resonance imaging ; differential diagnosis
- 刊名：Seminars in Arthritis and Rheumatism
- 出版年：2012
- 出版时间：December, 2012
- 年：2012
- 卷：42
- 期：3
- 页码：234-245
- 全文大小：1740 K
Objective
To investigate whether rheumatoid arthritis (RA) and psoriatic arthritis (PsA) can be differentiated in the early stages of the disease (duration of symptoms ¡Ü1 year) on the basis of magnetic resonance imaging (MRI) features of the hand and wrist.Material and methods
Twenty early RA and 17 early PsA patients with symptomatic involvement of the wrist and hand joints and inconclusive radiographic studies were examined prospectively with contrast-enhanced MRI. Images were evaluated in accordance with the Outcome Measures in Rheumatology Clinical Trials recommendations.
Results
Certain MRI features, such as the presence of enthesitis or extensive diaphyseal bone marrow edema, were observed exclusively in PsA (P = 0.0001). These distinctive findings were present in nearly 71 % (12/17) of PsA patients. Diffuse and, in some cases, pronounced soft-tissue edema spreading to the subcutis was also seen more frequently in patients with PsA (P = 0.002). There were no significant differences in the frequency of synovitis, bone erosions, subchondral bone edema, or tenosynovitis between the 2 groups. However, in RA extensor tendons were involved more often than the flexor tendons, whereas in PsA the opposite was observed (P = 0.014). With respect to the discriminatory power of the different MRI findings examined, only the presence of enthesitis or diaphyseal bone edema and, to a lesser extent, the pattern of hand tendon involvement and the presence of soft-tissue edema accurately differentiated PsA from RA (all these features achieved accuracies greater than 0.70).
Conclusions
We observed significant differences in the MRI findings of the hand and wrist that can help to distinguish between RA and PsA in the early stages of disease. This imaging method could help to assist in the differential diagnostic process in selected patients in whom diagnosis cannot be unequivocally established after conventional clinical, biochemical, and radiographic examinations.