Acyl CoA synthetase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male versus female mice
详细信息 查看全文
- 作者：Joseph R. Goldenberga ; b ; Xuerong Wanga ; E. Douglas Lewandowskia ; b ; c ; dougl@sbpdiscovery.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heart ; Cardiac metabolism ; Fatty acid uptake ; Ceramide ; Triglyceride ; Acyl CoA synthetase
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：1-9
- 全文大小：1061 K
文摘
- •
ACSL1 and female sex hormones accelerate fatty acid uptake rates in beating hearts.
- •
Faster female LCFA uptake rates require sex hormone-dependent ACSL1 expression.
- •
ACSL1 increases acyl derivative conversion to ceramide; no changes to TAG storage.
- •
Lipid trafficking of acyl derivatives differs between males and females.