Developmental manganese neurotoxicity in rats: Cognitive deficits in allocentric and egocentric learning and memory

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• 作者：Robyn M. Amos-Kroohs^a ; Laurie L. Davenport^b ; Nina Atanasova^c ; Zuhair I. Abdulla^d ; Matthew R. Skelton^a ; Charles V. Vorhees^a ; Michael T. Williams^a ; ^{michael.williams@cchmc.org}
• 关键词：Manganese ; Neurotoxicity ; Spatial learning ; Egocentric learning ; Alpha-synuclein ; Long-term potentiation
• 刊名：Neurotoxicology and Teratology
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：16-26
• 全文大小：1280 K
• 卷排序：59

文摘

Developmental manganese over-exposure (MnOE), low iron, and barren cage were tested. Developmental MnOE caused allocentric and egocentric learning and memory deficits. Barren cage also affected egocentric learning and memory. MnOE interacted with low Fe and/or barren cage in only a few instances. MnOE impaired LTP and altered striatal and hippocampal α-synuclein levels.